0852. Selective decontamination of the digestive tract modulates the metabolic profile in a ventilator-induced lung injury model
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0852. Selective decontamination of the digestive tract modulates the metabolic profile in a ventilator-induced lung injury model
Introduction Acute lung injury induced by mechanical ventilation [ventilator-induced lung injury (VILI)]is characterized by a particular metabolic profile in the lung and in the systemic compartment [1]. Also, VILI has been associated with an increase in intestinal permeability [2]. We hypothesized that selective decontamination of the digestive tract (SDD) can modulate the metabolic profile as...
متن کاملSelective decontamination of the digestive tract.
Ventilator-associated pneumonia usually originates from the patient's oropharyngeal microflora. In selective digestive decontamination, topical antibiotics are applied to the oropharynx and stomach for prevention of pneumonia and other infections, possibly reducing infection-related mortality. Selective digestive decontamination is also used for the prevention of gut-derived infections in acute...
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We read with interest the review entitled ‘‘Evidence on measures for the prevention of ventilator-associated pneumonia’’ by LORENTE et al. [1]. We enjoyed the paper as it is comprehensive and based on an appropriate design. In particular, we welcome the authors’ acknowledgement of the proven clinical benefits of selective decontamination of the digestive tract (SDD). The authors give four expla...
متن کاملSelective decontamination of the digestive tract and ventilator-associated pneumonia (part 1).
resistance in esophageal resection. Intensive Care Med 1990;16 Suppl 3:S224–228. 28. van der Voort PH, van Roon EN, Kampinga GA, Boerma EC, Gerritsen RT, Egbers PH, Kuiper MA. A before-after study of multiresistance and cost of selective decontamination of the digestive tract. Infection 2004; 32(5):271–277. 29. Diez-Roux AV. Bringing context back into epidemiology: variables and fallacies in mu...
متن کاملSelective decontamination of the digestive tract: all questions answered?
Although many studies have shown beneficial effects of SDD on the incidence of respiratory tract infections, SDD did not become routine practice because mortality reduction was not demonstrated in individual trials, beneficial effects on duration of ventilation, ICU stay or hospital stay were not demonstrated, cost-efficacy had not been demonstrated, and selection of antibiotic resistance was c...
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ژورنال
عنوان ژورنال: Intensive Care Medicine Experimental
سال: 2014
ISSN: 2197-425X
DOI: 10.1186/2197-425x-2-s1-p61